Monica's Lab

Publications

2024

Altered gene expression linked to germline dysfunction following exposure of Caenorhabditis elegans to DEET

Shin N, Lascarez-Lagunas LI, Henderson AL, Martinez-Garcia M, Karthikraj R, Barrera V, Sui SH, Kannan K, Colaiácovo MP.
iScience. 2024 Jan 4;27(1):108699. doi: 10.1016/j.isci.2023.108699. eCollection 2024 Jan 19. PMID: 38299026

2023

Germline mitotic quiescence and cell death are induced in Caenorhabditis elegans by exposure to pathogenic Pseudomonas aeruginosa.

Bollen DP, Reddy KC, Lascarez-Lagunas LI, Kim DH, Colaiácovo MP.
Genetics. 2023 Nov 13:iyad197. doi: 10.1093/genetics/iyad197. PMID: 37956057

The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.

Silva-García CG, Láscarez-Lagunas LI, Papsdorf K, Heintz C, Prabhakar A, Morrow CS, Pajuelo Torres L, Sharma A, Liu J, Colaiácovo MP, Brunet A, Mair WB.
Nat Aging. 2023 Nov;3(11):1358-1371. doi: 10.1038/s43587-023-00517-8. PMID: 37946042

GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.

Martinez-Garcia M, Naharro PR, Skinner MW, Baran KA, Lascarez-Lagunas LI, Nadarajan S, Shin N, Silva-Garcia CG, Saito TT, Beese-Sims S, Diaz-Pacheco BN, Berson E, Castaner AB, Pacheco S, Martinez-Perez E, Jordan PW, Colaiacovo MP.
PLoS Genet. 2023 Feb 21;19(2):e1010666. doi: 10.1371/journal.pgen.1010666. PMID: 36809245

Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans.

Lascarez-Lagunas LI, Martinez-Garcia M, Nadarajan S, Diaz-Pacheco BN, Berson E, Colaiácovo MP
PLoS Genet. 2023 Jan 27;19(1):e1010627. doi: 10.1371/journal.pgen.1010627. PMID: 36706157

2022

Beneficial antioxidant effects of Coenzyme Q10 on reproduction.

Hornos Carneiro MF and Colaiácovo MP.
Antioxidants. Vitamins & Hormones, Volume 120. Academic Press/Elsevier. Edited by Gerald Litwack. 2023;121:143-167. doi: 10.1016/bs.vh.2022.10.004. PMID: 36707133

ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice.

Láscarez-Lagunas LI, Nadarajan S, Martinez-Garcia M, Quinn JN, Todisco E, Thakkar T, Berson E, Eaford D, Crawley O, Montoya A, Faull P, Ferrandiz N, Barroso C, Labella S, Koury E, Smolikove S, Zetka M, Martinez-Perez E, Colaiácovo MP.
Curr Biol. 2022 Sept 14;S0960-9822(22)01403-8. doi: 10.1016/j.cub.2022.08.081. PMID: 36137547

Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Segregation.

Lascarez-Lagunas L, Martinez-Garcia M, Colaiácovo MP.
Genes. 2022 March 19;13(3):546. doi: 10.3390/genes13030546. PMID: 35328099

2021

Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

Zhang X, Tian S, Beese-Sims SE, Chen J, Shin N, Colaiácovo MP, Kim HM.
PLoS Genet. 2021 Jul 30;17(7):e1009715. doi: 10.1371/journal.pgen.1009715. Online ahead of print. PMID: 34329293

HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis

Nadarajan S, Altendorfer E, Saito TT, Martinez-Garcia M and Colaiácovo MP.
Proc Natl Acad Sci U S A (2021) Apr 27;118(17):e2016363118

Exposure to phthalates: germline dysfunction and aneuploidy

Henderson, A. and Colaiácovo M.
Prenatal Diagnosis (2021) Feb 14. doi: 10.1002/pd.5921. Online ahead of print.

2020

DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans

Láscarez-Lagunas L, Herruzo E, Grishok A, San-Segundo PA and Colaiácovo M.
PLoS Genet. 2020 Oct 26;16(10):e1009171.

SnapShot: Meiosis – Prophase I

Láscarez-Lagunas L, Martinez-Garcia M and Colaiácovo M.
Cell (2020) 181, 1442-1442.e1. DOI:https://doi.org/10.1016/j.cell.2020.04.038 .

Multivalent weak interactions between assembly units drive synaptonemal complex formation

Zhang Z, Xie S, Wang R, Guo S, Zhao Q, Nie H, Liu Y, Zhang F, Chen M, Liu L, Meng X, Liu M, Zhao L, Colaiácovo MP, Zhou J and Gao J.
Journal of Cell Biology (2020) 219 (5): e201910086. Online now: March 25, 2020. DOI:https://doi.org/10.1083/jcb.201910086 .

Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation

Altendorfer E, Láscarez-Lagunas LI, Nadarajan S, Mathieson I and Colaiácovo MP.
Current Biology (2020); Online now: March 05, 2020. DOI:https://doi.org/10.1016/j.cub.2020.01.079 .

Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline

Hornos Carneiro MF, Shin N, Karthikraj R, Barbosa F, Kannan K and Colaiácovo MP.
Genetics. 2020 Feb;214(2):381-395. doi: 10.1534/genetics.119.302939. Epub 2019 Dec 18. .

Environmentally-relevant Exposure to Diethylhexyl Phthalate (DEHP) Alters Regulation of Double-Strand Break Formation and Crossover Designation Leading to Germline Dysfunction in Caenorhabditis Elegans

Cuenca L, Shin N, Lascarez-Lagunas LI, Martinez-Garcia M, Nadarajan S, Karthikraj R, Kannan K and Colaiácovo MP.
PLoS Genetics (2020) 16 (1), e1008529 .

2019

Regulation of lifespan by neural excitation and REST.

Zullo JM, Drake D, Aron L, O´Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Colaiácovo MP, and Yankner BA.
Nature (2019); 574(7778):359-364. .

The demethylase NMAD-1 regulates DNA replication and repair in the C. elegans germline.

Wang SY, Mao H, Shibuya H, Uzawa S, O’Brown ZK, Wesenberg S, Shin N, Saito TT, Gao J, Meyer BJ, Colaiácovo MP, and Greer EL.
PLoS Genetics (2019)Jul 8;15(7):e1008252.

Progression of Meiosis is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans.

Achache H, Laurent L, Hecker-Mimoun Y, Ishtayeh H, Rappaport Y, Kroizer E, Colaiácovo MP and Tzur YB
Genetics (2019); 212(1):213-229.

Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans.

Shin N, Cuenca L, Karthikraj R, Kannan K and Colaiácovo MP
PLoS Genetics 2019 Feb 14;15(2):e1007975

2018

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans.

Qianyan Li, Takamune T. Saito, Marina Martinez-Garcia, Alison J. Deshong, Saravanapriah Nadarajan, Katherine S. Lawrence, Paula M. Checchi, Monica P. Colaiacovo, JoAnne Engebrecht
PLoS Genet. 2018 Nov 1;14(11):e1007701. doi: 10.1371/journal.pgen.1007701. eCollection 2018 Nov. [Epub ahead of print]

α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease.

Cooper JF, Spielbauer KK, Senchuk MM, Nadarajan S, Colaiácovo MP, Van Raamsdonk JM.
Exp Neurol. 2018 Sep 5. pii: S0014-4886(18)30432-1. doi: 10.1016/j.expneurol.2018.09.001. [Epub ahead of print]

Spatiotemporal Gene Expression Analysis of the Caenorhabditis elegans Germline Uncovers a Syncytial Expression Switch.

Yonatan B. Tzur, Eitan Winter, Jinmin Gao, Tamar Hashimshony, Itai Yanai and Monica P. Colaiácovo
GENETICS October 1, 2018 vol. 210 no. 2 587-605; https://doi.org/10.1534/genetics.118.301315

Zipping and unzipping: protein modifications regulating synaptonemal complex dynamics.

Gao J and Colaiacovo MP.
Trends Genet. 2018 Mar;34(3):232-245. doi: 10.1016/j.tig.2017.12.001. Epub 2017 Dec 28..

Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 are required for maintaining histone methylation levels and interact with the histone demethylase LSD1/SPR-5 in C. elegans.

Kim HM, Beese-Sims SE and Colaiácovo MP.
GENETICS Early online March 27, 2018; https://doi.org/10.1534/genetics.118.300823

Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.

Ferrandiz N, Barroso C, Telecan O, Shao N, Kim HM, Testori S, Faull P, Cutillas P, Snijders AP, Colaiácovo MP, Martinez-Perez E.
Nat Commun. 2018 Feb 26;9(1):834.

Publications

2024

Altered gene expression linked to germline dysfunction following exposure of Caenorhabditis elegans to DEET

2023

Germline mitotic quiescence and cell death are induced in Caenorhabditis elegans by exposure to pathogenic Pseudomonas aeruginosa.

The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.

GRAS-1 is a novel regulator of early meiotic chromosome dynamics in C. elegans.

Chromatin landscape, DSB levels, and cKU-70/80 contribute to patterning of meiotic DSB processing along chromosomes in C. elegans.

2022

Beneficial antioxidant effects of Coenzyme Q10 on reproduction.

ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice.

Loss, Gain, and Retention: Mechanisms Driving Late Prophase I Chromosome Remodeling for Accurate Meiotic Segregation.

2021

Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.

HIM-17 regulates the position of recombination events and GSP-1/2 localization to establish short arm identity on bivalents in meiosis

Exposure to phthalates: germline dysfunction and aneuploidy

2020

DOT-1.1-dependent H3K79 methylation promotes normal meiotic progression and meiotic checkpoint function in C. elegans

SnapShot: Meiosis – Prophase I

Multivalent weak interactions between assembly units drive synaptonemal complex formation

Crossover Position Drives Chromosome Remodeling for Accurate Meiotic Chromosome Segregation

Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline

Environmentally-relevant Exposure to Diethylhexyl Phthalate (DEHP) Alters Regulation of Double-Strand Break Formation and Crossover Designation Leading to Germline Dysfunction in Caenorhabditis Elegans

2019

Regulation of lifespan by neural excitation and REST.

The demethylase NMAD-1 regulates DNA replication and repair in the C. elegans germline.

Progression of Meiosis is Coordinated by the Level and Location of MAPK Activation Via OGR-2 in Caenorhabditis elegans.

Assessing effects of germline exposure to environmental toxicants by high-throughput screening in C. elegans.

2018

The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans.

α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease.

Spatiotemporal Gene Expression Analysis of the Caenorhabditis elegans Germline Uncovers a Syncytial Expression Switch.

Zipping and unzipping: protein modifications regulating synaptonemal complex dynamics.

Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 are required for maintaining histone methylation levels and interact with the histone demethylase LSD1/SPR-5 in C. elegans.

Spatiotemporal regulation of Aurora B recruitment ensures release of cohesion during C. elegans oocyte meiosis.

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