Phone: 1-617-432-6543

News

Our new study in bioRχiv about FANC pathway in DNA repair and histone modification.

Admin
Feb, 2018
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The histone demethylase LSD1 was originally discovered as removing methyl groups from di- and monomethylated histone H3 lysine 4 (H3K4me2/1), and several studies suggest it plays roles in meiosis as well as epigenetic sterility given that in its absence there is evidence of a progressive accumulation of H3K4me2 through generations. In addition to transgenerational sterility, growing evidence for the importance of histone methylation in the regulation of DNA damage repair has attracted more attention to the field in recent years. However, we are still far from understanding the mechanisms by which histone methylation is involved in DNA damage repair and only a few studies have been focused on the roles of histone demethylases in germline maintenance. Here, we show that the histone demethylase LSD1/CeSPR-5 is interacting with the Fanconi Anemia (FA) protein FANCM/CeFNCM-1 based on biochemical, cytological and genetic analyses. LSD1/CeSPR-5 is required for replication stress-induced S-phase checkpoint activation and its absence suppresses the embryonic lethality and larval arrest observed in fncm-1 mutants. FANCM/CeFNCM-1 re-localizes upon hydroxyurea exposure and co-localizes with FANCD2/CeFCD-2 and LSD1/CeSPR-5 suggesting coordination between this histone demethylase and FA components to resolve replication stress. Surprisingly, the FA pathway is required for H3K4me2 maintenance regardless of the presence of replication stress. Our study reveals a connection between Fanconi Anemia and epigenetic maintenance, therefore providing new mechanistic insight into the regulation of histone methylation in DNA repair.

Link to Preprint

Monica is interviewed in Harvard Medicine magazine (Autumn 2017; Volume 90, Number 3)

Admin
Nov, 2017
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This latest issue of Harvard Medicine Magazine is focused on the environment. Monica talks about the research from our lab looking into how reproductive health is impacted due to exposures to common chemicals present in our environment.

Link to Harvard Medical Magazine

Monica became an editorial board member of PLOS Genetics!

Admin
Apr, 2016
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PLOS Genetics publishes human studies, as well as research on model organisms—from mice and flies, to plants and bacteria. Their emphasis is on studies of broad interest that provide significant insight into a biological process or processes. Topics include (but are not limited to) gene discovery and function, population genetics, genome projects, comparative and functional genomics, medical genetics, disease biology, evolution, gene expression, complex traits, chromosome biology, and epigenetics.

Link to PLOS Genetics

2016 Department of Genetics Retreat Poster Winner

Admin
Feb, 2016
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Nara Shin was a poster presentation winner at the 2016 Department of Genetics Retreat!
She presented her work on: "Assessing Germline Exposure to Environmental Toxicants by High-Throughput Screening in C. elegans"

Dr. Colaiacovo is now a Tenured Full professor

Admin
Jul, 2015

The Faces of HMS: A Q&A with Monica Colaiacovo interview

Admin
Jul, 2014

You can read this interesting interview of Monica Colaiacovo for @HMS

Read the iterview

Green Eggs and HIM:Uncovering the reproductive effects of chemical exposure

Admin
Jun, 2014
@HMS writes an article and records a video about the lab's work regarding the effects of chemical exposures in meiosis

Monica on Science Matters video

Admin
Nov, 2013

Contact Details

Dr. Monica Colaiacovo
Harvard Medical School, Department of Genetics 
New Research Building, Room 334 
77 Avenue Louis Pasteur, Boston, MA 02115 USA 
Telephone: 1-617-432-6543
Email: mcolaiacovo@genetics.med.harvard.edu