This lecture will be better annotated soon

Identifying regulatory networks by combinatorial analysis of promoter elements

9/28/01


Click here to start


Table of Contents

Combinatorics of promoter regulatory elements determines gene expression profiles

Goals of study

PPT Slide

In case of two motifs derived from a cluster

Two motifs derived from the same cell-cycle cluster

PPT Slide

Condition-specific TF-TF interaction can be identified (in cell cycle)

PPT Slide

PPT Slide

PPT Slide

Expression experiments used

PPT Slide

PPT Slide

Identification of functional motifs

PPT Slide

For two motifs, RRPE and PAC

For every combination of N=2,3 motifs

Ribosomal motifs

Cell cycle and sporulation motifs

PPT Slide

PPT Slide

PPT Slide

From the literature: 1)Meiotic role of SWI6 in (Nucleic Acids Res. 1998) 2) Role for MCB in sporulation (Nature Genetics 2001)

PPT Slide

What can we infer about specific network architecture ?

A global motif interaction map

What can we learns about global interaction ?

Acknowledgments

PPT Slide

Author: Tzachi Pilpel

Email: tpilpel@genetics.med.harvard.edu

Home Page: http://genetics.med.harvard.edu/~tpilpel

Other information:
Yitzhak (Tzachi) Pilpel Dept. of Genetics, Harvard

Download presentation source