The Seidman Lab is the research base for a human molecular genetics program co-directed by Christine E. Seidman, MD and Jonathan G. Seidman, PhD. Located within the Departments of Genetics at Harvard Medical School and the Cardiovascular Division of Brigham and Women's Hospital, the laboratory harnesses and integrates clinical medicine and molecular technologies to define disease-causing gene mutations and genetic variations that increase disease risk. The laboratory also develops and interrogates genetically engineered models to elucidate pathogenetic mechanisms for human disease. Major research projects focus on discovery of the genetic contributions to cardiovascular disease (including dilated and hypertrophic cardiomyopathy, coronary artery disease and congenital heart disease), hearing loss, and lymphedema. Through collaborative interactions with the Cardiovascular Genetics Center (Brigham and Women's Hospital) and Massachusetts Eye and Ear Infirmary, the Seidman laboratory translates basic research discoveries into better diagnostics and improved management strategies, and opportunities for developing novel therapeutics to treat disease.