Research
Papers
1) Perrimon,
N. and Gans, M. (1983) Clonal analysis of the tissue specificity
of recessive female sterile mutations of Drosophilamelanogaster using
a dominant female sterile mutation Fs(1)K1237. Dev. Biol. 100, 365-373.
PDF
2) Perrimon, N. (1984) Clonal analysis of dominant female sterile, germline-
dependent mutations in Drosophila melanogaster. Genetics 108, 927-939.
PDF
3) White,
R. H., Perrimon, N and Gehring, W. J. (1984) Differentiation markers
in Drosophila ovary. J. E. E. M. 84, 275-286. PDF
4) Perrimon,
N., Engstrom, L., and Mahowald, A. P. (1984). The effects of zygotic
lethal mutations on female germ-line functions in Drosophila. Dev.
Biol. 105, 404-414.PDF
5) Perrimon,
N., Engstrom, L., and Mahowald, A. P. (1984). Developmental genetics
of the 2E-F region of the Drosophila X-chromosome: A region rich in "developmentally
important " genes. Genetics 108, 559-572. PDF
6) Perrimon,
N., Engstrom, L., and Mahowald, A. P. (1985). A pupal lethal mutation
with a paternally influenced maternal effect on embryonic development
in Drosophila melanogaster. Dev. Biol. 110, 480-491PDF
7) Perrimon,
N., Engstrom, L., and Mahowald, A. P. (1985). Developmental genetics
of the 2C-D region of the Drosophila X-chromosome. Genetics 111, 23-41.
PDF
8) Mortin,
M. A., Perrimon, N. and Bonner, J. J (1985) Clonal analysis of two
mutations in the large subunit of RNA polymerase II of Drosophila. Mol.
Gen. Genet. 199, 421-426. PDF
9) Degelmann,
A., Hardy, P., Perrimon, N. and Mahowald, A. P. (1986) Developmental
analysis of the torso-like phenotype in Drosophila produced by maternal
effect locus. Dev. Biol. 115, 479-489.PDF
10) Perrimon,
N., Mohler, J. D., Engstrom, L and Mahowald, A. P. (1986) X-linked
female sterile loci in Drosophila melanogaster. Genetics 113, 695-712.PDF
11) Perrimon,
N. and Mahowald, A. P. (1986) l(1)hopscotch a larval-pupal lethal
with a specific maternal effect on segmentation in Drosophila. Dev.
Biol. 118, 28-41. PDF
12) Petschek,
J., Perrimon, N., and Mahowald, A. P. (1987). Region specific effects
in l(1)giant embryos of Drosophila melanogaster. Dev. Biol. 119, 175-189.
PDF
13) Perrimon,
N. and Mahowald, A. P. (1987) Multiple functions of the segment
polarity genes in Drosophila. Dev. Biol. 119, 587-600. PDF
14) Mark,
G. E., MacIntyre, R. J., Digan, M. E., Ambrosio, L. and Perrimon,
N. (1987) Drosophila melanogaster homologs of the raf oncogene. Mol. Cell.
Biol. 7, 2134-2140. PDF
15) Oliver,
B., Perrimon, N. and Mahowald, A. P. (1987) The ovo locus is required
for sex specific germ line maintenance in Drosophila. Genes and Dev. 1,
913-923. PDF
16) Perrimon,
N. (1988) The maternal effect of l(1)discs-large-1, a recessive oncogene
in Drosophila melanogaster. Dev. Biol. 127, 392-407. PDF
17) Oliver,
B., Perrimon, N. and Mahowald, A. P. (1988) Genetics evidence that
the sans-fille locus is involved in Drosophila sex determination. Genetics
120, 159-171.PDF
18) Smouse,
D., Goodman, C., Mahowald, A. P. and Perrimon, N. (1988) polyhomeotic:
A gene required for the embryonic development of axon pathways in the
central nervous system of Drosophila. Genes and Dev. 2, 830-842.PDF
19) Ng,
S-C., Perkins, L. A., Conboy, G., Perrimon, N. and Fishmann, M. (1989)
A Drosophila gene expressed in the embryonic CNS shares one conserved
domain with the mammalian GAP-43. Development. 105, 629-638. PDF
20) Perrimon,
N., Engstrom, L., and Mahowald, A. P. (1989) Zygotic lethals with
specific maternal effect phenotypes in Drosophila melanogaster. I. Loci
on the X-chromosome. Genetics 121, 333-352. PDF
21) Perrimon,
N., Smouse, D. T. and Miklos, G. L. G. (1989) Developmental genetics
of loci at the base of the X-chromosome of Drosophila melanogaster. Genetics
121, 313-331. PDF
22) Perrimon,
N., and Smouse, D. (1989) Multiple functions of a Drosophila homeotic
gene, zeste-white 3, during segmentation and neurogenesis Dev. Biol. 135,
287-305. PDF
23) Klingensmith,
J., Noll, E. and Perrimon, N. (1989) The segment polarity phenotype
of Drosophila involves differential tendencies toward transformation and
cell death. Dev. Biol. 134, 130-145. PDF
24) Ambrosio,
L. Mahowald, A. P. and Perrimon, N. (1989) l(1)pole hole is required
maternally for pattern formation in the terminal regions of the embryo.
Development 106, 145-158. PDF
25) Ambrosio,
L. Mahowald, A. P. and Perrimon, N. (1989) Requirement of the Drosophila
raf homologue for torso function. Nature 342, 288-291. PDF
26) Perkins,
L. A., Doctor, J. S., Zhang, K., Stinson, L., Perrimon, N. and Craig.
E. A. (1990) Molecular and developmental characterization of the heat
shock cognate 4 gene of Drosophila melanogaster. Mol. Cell. Biol. 10,
3232-3238. PDF
27) Smouse,
D. T. and Perrimon, N. (1990) Genetic dissection of a complex neurological
mutant, polyhomeotic, in Drosophila. Dev. Biol. 139, 169-185. PDF
28) Zhang,
K., Chaillet, R., Perkins, L. A., Halazonetis, T. and Perrimon, N.
(1990) Drosophila homolog of the mammalian jun oncogene is expressed during
embryonic development and activates transcription in mammalian cells.
P.N.A.S. 87, 6281-6285. PDF
29) Finkelstein,
R., Smouse. D. T., Capaci, T., Spradling, A. C. and Perrimon, N. (1990)
The orthodenticle gene encodes a novel homeodomain protein involved in
the development of the Drosophila nervous system and ocellar visual structures.
Genes and Dev. 4, 1516-1527. PDF
30) Finkelstein,
R. and Perrimon, N. (1990) The orthodenticle gene is regulated by
bicoid and torso and specifies Drosophila head development. Nature 346,
485-488. PDF
31) Siegfried,
E., Perkins, L. A., Capaci, T. M. and Perrimon, N. (1990) Putative protein kinase product of the Drosophila segment-polarity gene, zeste-white
3. Nature 345, 825-829.
32)
Zhang, K. Smouse, D. T. and N. Perrimon (1991) The crooked neck gene
of Drosophila contains a motif found in a family of yeast cell cycle genes.
Genes and Dev. 5, 1080-1091. PDF
33) Perrimon,
N., Noll, E., McCall, K. and Brand, A. (1991) Generating lineage-specific
markers to study Drosophila development. Dev. Genet. 12, 238-252. PDF
34) Eberl,
D. Perkins, L. A., Engelstein, M., Hilliker, A., and N. Perrimon.
(1992) Developmental genetics of loci in region 17 of the X-chromosome
of Drosophila melanogaster. Genetics 130, 569-583. PDF
35) Kassis,
J. A., Noll, E., VanSickle, E., Odenwald, W. and N. Perrimon. (1992)
Altering the insertion specificity of a Drosophila transposable element.
P.N.A.S. 89, 1919-1923. PDF
36) Chou
T. B., and N. Perrimon (1992) Use of a yeast site-specific recombinase
to produce female germline chimeras in Drosophila. Genetics 131, 643-653. PDF
37) Perkins,
L. A., Larsen, I., and Perrimon, N. (1992) Corkscrew encodes a putative
protein tyrosine phosphatase that functions to transduce the terminal
signal from the receptor tyrosine kinase torso. Cell 70, 225-236. PDF
38) Rutledge,
B., Zhang, K., Bier, E., Jan, Y. N. and Perrimon, N. (1992) The Drosophila
spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral
axis formation and neurogenesis. Genes and Dev. 6, 1503-1517. PDF
39) Wieschaus,
E., Perrimon, N. and Finkelstein, R. (1992) Orthodenticle activity
is required for the development of medial structures in the larval and
adult epidermis of Drosophila. Development 115, 801-811. PDF
40) Siegfried,
E. Chou, T-B, and Perrimon, N. (1992) Wingless signaling acts through
zeste-white 3, the Drosophila homologue of glycogen synthase kinase-3,
to regulate engrailed and establish cell fate. Cell 71, 1167-1179. PDF
41) Dang,
D. T. and Perrimon, N (1992) Use of a yeast site-specific recombinase
to generate embryonic mosaics in Drosophila. Dev. Genetics. 13, 367-375.
PDF
42) Lu,
X. Chou T. B, Williams, N., Roberts, T. and Perrimon, N. (1993) Control
of cell fate determination by p21ras/Ras1, an essential component of torso
signaling in Drosophila. Genes and Dev. 7, 621-632. PDF
43) Melnick,
M. B. Perkins, L. A., Lee, M., Ambrosio, L. Perrimon, N. (1993) Developmental
and molecular characterization of mutations in the Drosophila raf serine-threonine
protein kinase. Development 118, 127-138. PDF
44) Brand,
A. and Perrimon, N. (1993) Targeted gene expression as a means of
altering cell fates and generating dominant phenotypes. Development 118,
401-415.PDF
45) Harrison,
D. and Perrimon, N. (1993) Simple and efficient generation of marked
clones in Drosophila. Current Biology. 3, 424-433. PDF
46) Melnick,
M. B., Noll, E. and Perrimon, N. (1993) The Drosophila stubarista
phenotype is associated with a dosage effect of the putative ribosome-associated
protein D-p40 on spineless. Genetics 135, 553-564. PDF
47) Chou,
T.-B., Noll, E. and Perrimon, N. (1993) Autosomal P[ovoD1] dominant
female sterile insertions in Drosophila and their use in generating germline
chimeras. Development 119, 1359-1369. PDF
48) van
den Heuvel, M., Harryman-Samos, C., Klingensmith, J., Perrimon, N.
and Nusse, R. (1993) Mutations in the segment polarity genes wingless
and porcupine impair secretion of the wingless protein. EMBO. J. 12, 5293-5303.PDF
49) Siegfried,
E., Wilder, E. and Perrimon, N. (1994) Components of wingless signaling
in Drosophila. Nature 367, 76-80. PDF
50)
Noordermeer, J., Klingensmith, J., Perrimon, N. and Nusse, R. (1994) Dishevelled
and armadillo are essential components of the wingless signaling pathway
in Drosophila. Nature 367, 80-83. PDF
51) Klingensmith,
J., Nusse, R. and Perrimon, N. (1994) The Drosophila segment polarity
gene dishevelled encodes a novel protein required for response to the
wingless signal. Genes and Dev. 8, 118-130. PDF
52) Binari,
R. and Perrimon, N. (1994) Stripe-specific regulation of pair-rule
genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila.
Genes and Dev. 8, 300-312. PDF
53) Brand,
A. and Perrimon, N. (1994) Raf acts downstream of the EGF receptor
to determine dorso-ventral polarity during Drosophila oogenesis. Genes and Dev. 8, 629-639. PDF
54) Lu,
X., Melnick, M.B., Hsu, J-C. and Perrimon, N. (1994). Genetics and
molecular analysis of mutations involved in Drosophila-raf signal transduction.
EMBO J. 13, 2592-2599.PDF
55) Hsu,
J-C. and Perrimon, N. (1994). A temperature sensitive MEK mutation
demonstrates the conservation of the signaling pathways activated by receptor
tyrosine kinases. Genes and Dev. 8, 2176-2187. PDF
56) Sussman,
D.J., Klingensmith, J., Salinas, P., Adams, P. S., Nusse, R. and Perrimon,
N. (1994) Isolation and characterization of a mouse homolog of the Drosophila
dishevelled segment polarity gene. Dev. Biol. 166, 73-86. PDF
57) Wilder,
E.L. and Perrimon, N. (1995). Dual functions of wingless in the Drosophila
leg imaginal disc. Development 121, 477-488. PDF
56) Hou,
X.S., Chou, T.-B., Melnick, M. and Perrimon, N. (1995). The Torso
receptor tyrosine kinase can activate Raf in a Ras-independent pathway.
Cell 81, 63-7.PDF
57) Sokol,
S.Y., Klingensmith, J., Perrimon, N. and Itoh, K. (1995). Dorsalizing
and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog
of dishevelled. Development. 121, 1637-1647. PDF
58) Harrison,
D.A., Binari, R., Nahreini, T. S., Gilman, M. and Perrimon, N. (1995)
Activation of a Drosophila janus kinase (JAK) causes hematopoietic neoplasia
and developmental defects. EMBO. J. 14, 2857-2865. PDF
59) Rivera-Pomar,
R., Lu, X., Perrimon, N., Taubert, H. and Jackle, H. (1995) Activation
of posterior gap gene expression in the Drosophila blastoderm. Nature
376, 253-256.PDF
60) Yoffe,
K., Manoukian, A., Wilder, E., Brand, A. and Perrimon, N. (1995) Evidence
for engrailed-independent wingless autoregulation in Drosophila. Dev.
Biol. 170, 636-650.PDF
61) Yin,
J.C.P., Wallach, J.S., Wilder, E.L., Klingensmith, J., Dang, D., Perrimon,
N., Zhou, H., Tully, T. and Quinn, W.G. (1995) A Drosophila CREB/CREM homolog
encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive
transcriptional activator and antagonist. Mol. Cell. Biol. 15, 5123-5130.
PDF
62) Manoukian,
A.S., Yoffe, K., Wilder, E.L. and Perrimon, N. (1995) The porcupine
gene is required for wingless autoregulation in Drosophila. Development
121, 4037-4044. PDF
63) Hou,
X.S., Melnick, M.B. and Perrimon, N. (1996) Marelle acts downstream
of the Drosophila Hop/JAK kinase and encodes a protein similar to the
mammalian STATs. Cell 84, 411-420. PDF
64) Cleghon,
V., Gayko, U., Copeland, T.D., Perkins, L.A., Perrimon, N. and Morrison,
D.K. (1996). Drosophila terminal structure development is regulated by
the compensatory activities of positive and negative phosphotyrosine signaling
sites on the Torso RTK. Genes Dev. 10, 566-577. PDF
65) Axelrod,
J., Matsuno, K., Artavanis-Tsakonas, S. and Perrimon, N. (1996). Dishevelled
mediates interaction between Wingless and Notch signaling pathways. Science
271, 1826-1832. PDF
66) Musacchio
M. and Perrimon N. (1996) The Drosophila kekkon genes: novel members
of both the leucine-rich repeat and immunoglobulin superfamilies expresed
in the CNS. Dev Biol. 78, 63-76. PDF
67) Klingensmith,
J., Yang Y., Axelrod J. D., Beier D. R., Perrimon N. and Sussman D.
J. (1996) Conservation of dishevelled structure and function between flies
and mice: isolation and characterization of Dvl2. Mech Dev. 58, 15-26.
PDF
68) Perkins,
L.A., Johnson, M.R., Melnick, M.B. and Perrimon, N. (1996). The non-receptor
protein tyrosine phosphatase Corkscrew functions in multiple receptor
tyrosine kinase pathways in Drosophila. Dev. Biol. 180, 63-81. PDF
69) Kadowaki,
T., Wilder, E., Klingensmith, J.,s Zachary, K. and Perrimon, N. (1996).
The segment polarity gene porcupine encodes a putative multitransmembrane
protein involved in Wingless processing. Genes and Dev. 15, 3116-3128.
PDF
70) Rulifson,
E.J., Micchelli, C.A., Axelrod, J.D., Halevy, M., Perrimon, N. and
Blair, S. (1996). Wingless refines its own expression domain on the Drosophila
wing margin. Nature 384, 72-74.PDF
71) Chou,
T.-B. and Perrimon, N. (1996). The autosomal FLP-DFS technique for
generating germline mosaics in Drosophila melanogaster. Genetics 144,
1673-1679. PDF
72) Perrimon,
N., Lanjuin, A., Arnold, C. and Noll, E. (1996). Zygotic lethal mutations
with maternal effect phenotypes in Drosophila melanogaster. II. Loci on
the second and third chromosomes identified by P-element induced mutations.
Genetics 144, 1681-1692. PDF
73) Goode,
S., Melnick, M.B., Chou, T.-B. and Perrimon, N. (1996). The role of
Egghead during morphogenesis of the follicular cell epithelium. Development
122, 3863-3879. PDF
74) Hou,
X.S. and Perrimon, S. (1997). The JAK/STAT pathway in Drosophila.
TIG. 13, 105-110. PDF
75) Yu,
Y., Li, W., Su, K., Yssa, M., Han, W., Perrimon, N. and Pick, L. (1997).
The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain
protein Fushi Tarazu. Nature 385, 552-555. PDF
76) Eberl,
D., Lorenz, L.J., Melnick, M.B., F., Sood, V., Lasko, P. and Perrimon,
N. (1997). A new enhancer of position-effect variegation in Drosophila
melanogaster encodes a putative RNA helicase that binds chromosomes and
is regulated by the cell cycle. Genetics 146, 951-963. PDF
77) Hou,
X.S., Goldstein, E.S. and Perrimon, N. (1997). Drosophila Jun relays
the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic
signal transduction pathway in regulating epithelial cell sheet movement.
Genes and Dev. 11, 1728-1737. PDF
78) Goode,
S. and Perrimon, N. (1997). Inhibition of patterned cell shape change
and cell invasion by Discs large during Drosophila oogenesis. Genes and
Dev. 11, 2532-2544. PDF
79) Haecker,
U., Lin, X. and Perrimon, N (1997) The Drosophila Sugarless gene modulates
Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.
Development 124, 3565-3573. PDF
80) Li,
W., Skoulakis, E.M.C., Davis, R.L. and Perrimon, N. (1997). The Drosophila
14-3-3 protein leonardo enhances torso signaling through D-raf in a Ras1-dependent
manner. Development 124, 4163-4171. PDF
81) Eberl,
D., Duyk, G.M. and Perrimon, N. (1997) A genetic screen for mutations
that disrupt an auditory response in Drosophila melanogaster. P.N.A.S.
94, 14837-14842. PDF
82) Haecker,
U. and Perrimon, N. (1998) The DRho- GEF2 encodes a member of the
Dbl family of oncogenes and controls cell shape changes during gastrulation
in Drosophila. Genes and Dev. 12, 274-284. PDF
83) Duffy,
J.B., Harrison, D.A. and Perrimon, N. (1998). Identifying loci required
for follicular patterning using directed mosaics. Development 125, 2263-2271.
PDF
84) Bellaiche,
Y., The, I. and Perrimon, N.(1998) Tout-velu, a Drosophila homologue
of the putative tumor suppressor gene Ext-1, is required for the diffusion
of the hedgehog protein. Nature 394, 85-88. PDF
85) Perrimon,
N. (1998) New advances in Drosophila provide opportunities to study
gene functions. P.N.A.S. 95, 9716-9717. PDF
86) Axelrod,
J.D., Miller, J.R., Shulman, J.M., Moon, R.T. and Perrimon, N. (1998)
Differential recruitment of Dishevelled provides signaling specificity
in the Wingless and Planar Cell Polarity signaling pathways. Genes and
Dev. 12, 2610-2622.PDF
87) Harrison,
D.A., McCoon, P.E., Binari, R., Gilman, M. and Perrimon, N. (1998)
Drosophila unpaired encodes a secreted protein that activates the JAK
signaling pathway. Genes and Development 12, 3252-3263. PDF
88) Cleghon,
V., Feldmann, P., Ghiglione, C., Copeland, T.D., Perrimon, N., Hughes,
D.A., and Morrison, D.K. (1998). Opposing actions of CSW and RasGAP modulate
the strength of Torso RTK signaling in the Drosophila terminal pathway.
Molecular Cell 2, 719-727. PDF
89) Li,
W., Melnick, M. and Perrimon, N. (1998) Dual Function of Ras in Raf activation. Development 125, 4999-5008. PDF
90) Ghiglione,
C., Perrimon, N., and Perkins, L. (1999) Quantitative variations in
the level of MAPK activity controls patterning of the embryonic termini
in Drosophila. Dev. Biol. 205, 181-193. PDF
91) Gayko,
U., Cleghon, V., Copeland, T., Morrison, D. K., and Perrimon, N. (1999).
Synergistic activities of multiple phosphotyrosine residues mediate full
signaling from the Drosophila Torso Receptor Tyrosine Kinase. P.N.A.S.
96, 523-528. PDF
92) Ghiglione,
C., Carraway, K.L., Amundadottir, L.T., Boswell, R.E., Perrimon, N.*,
and Duffy, J.B.* (1999). The transmembrane molecule Kekkon 1 acts in a
feed back loop to negatively regulate the activity of the Drosophila EGF
receptor during oogenesis.* Co-senior and corresponding authors.Cell 96,
847-856. PDF
93)
Zeidler, M. P., Perrimon, N. and Strutt, D.I.(1999). Polarity determination
in the Drosophila eye: a novel role for Unpaired and JAK/STAT signalling.
Genes and Development 13, 1342-1353. PDF
94) Bellaiche,
Y., Mogila, V. and Perrimon, N. (1999). I-SceI endonuclease, a new
tool for studying DNA double stand break repair mechanisms in Drosophila.
Genetics 152, 1037-1044. PDF
95) Lin,
X., and Perrimon, N. (1999) Dally cooperates with Drosophila Frizzled
2 to transduce Wingless signaling. Nature 400, 218-284. PDF
96) Lin,
X., Buff, E.M., Perrimon, N., and Michelson, A.M. (1999) Heparan sulfate
proteoglycans are essential for FGF receptor signaling during Drosophila
embryonic development. Development 126, 3715-3723. PDF
97) The,
I., Bellaiche, and Perrimon, N. (1999) Evidence that movement of Hedgehog
in Drosophila tissues is regulated by a specific Heparan Sulfate Proteoglycans.
Molecular Cell 4, 633-639. PDF
98) Martin
Blanco, E., Roch, F., Noll, E., Baonza, A., Duffy, J.B., and Perrimon,
N. (1999) A temporal switch in DER signaling controls the specification
and differentiation of veins and interveins in the Drosophila wing. Development
126, 5739-5747. PDF
99) Zeidler,
M. P., Perrimon, N. and Strutt, D.I.(1999) The four jointed gene is
required in the Drosophila eye for ommatidial polarity specification.
Current Biology 9, 1363-1372. PDF
100) Bilder,
D. and Perrimon, N. (2000) Localization of apical epithelial determinants
by the basolateral PDZ protein Scribble. Nature 403, 676-680. PDF
101) Bilder,
D., Li, M. and Perrimon, N. (2000) Cooperative regulation of cell
polarity and growth by Drosophila tumor suppressors. Science 289, 113-116.
PDF
102) Baum,
B., Li, W. and Perrimon, N. (2000) A cyclase-associated protein regulates
actin and cell polarity during Drosophila oogenesis and in yeast. Current
Biology 10, 964-973. PDF
103) Li,
W., Noll, E. and Perrimon, N. (2000) Identification of autosomal regions
involved in Drosophila Raf function. Genetics 156, 763-774. PDF
104) Noll,
E., Medina, M., Hartley, D., Zhou J., Perrimon, N and Kosik. K. S.
(2000) Presenilin Affects Arm/b-Catenin Localization and Function in Drosophila.
Dev Biol. 227, 450-464. PDF
105) Tanaka,
K., Okabayashi, K., Asashima, M., Perrimon, N. and Kadowaki, T. (2000)
The evolutionarily conserved porcupine gene family is involved in the
processing of the Wnt family. Eur J. Biochem. 267, 4300-11. PDF
106) Zeidler,
M. P., Perrimon, N. and Strutt, D.I.(2000) Multiple roles for four
jointed in planar polarity and limb patterning. Dev Biol. 228, 181-196.
PDF
107) Baeg,
G. H., Lin, X., Khare, N., Baumgartner, S. and Perrimon, N. (2001)
Heparan sulfate proteoglycans are critical for the organization of the
extracellular distribution of Wingless. Development 128, 87-94. PDF
108) Bai,
J. M., Wang, J. C., Chiu, W.S., Perrimon, N. and Hsu, J.C. (2001)
The cell adhesion molecule Echinoid defines a new pathway that antagonizes
the Drosophila EGF receptor signaling pathway. Development 128, 591-601.
PDF
109) Baum,
B. and Perrimon, N. (2001) Spatial organization of the actin cytoskeleton
in Drosophila epithelial cells. Nature Cell Biology 3, 883-890. PDF
110) Selva,
E., Hong, K., Baeg, G. H., Beverley, S. M., Turco, S. J., Perrimon,
N. and Haecker, U. (2001) Dual Role of the fringe connection gene in both
Heparan Sulfate and fringe-dependent signaling events. Nature Cell Biology
3, 809-815. PDF
111) Stronach,
B. E. and Perrimon, N. (2001) Investigation of leading edge formation
at the interface of amnioserosa and dorsal ectoderm in the Drosophila
embryo.Development 128, 2905-2913. PDF
112) Suzanne,
M., Perrimon, N. and Noselli, S. (2001). The Drosophila JNK pathway
controls the morphogenesis of the egg dorsal appendages and micropyle.
Dev Biol. 237, 282-294. PDF
113) Hong,
Y., Stronach, B., Perrimon, N, Jan, L. Y. and Jan, Y. N. (2001) Drosophila
stardust interacts with Crumbs to control polarity of epithelia but not
neuroblasts in Drosophila. Nature 414, 634-638. PDF Supplement
114) Ghiglione,
C., Bach, E., Paraiso, Y., Carraway, K., Noselli, S. and Perrimon,
N. (2002) Mechanism of activation of the Drosophila EGF Receptor by the
TGFa ligand Gurken during oogenesis. Development 129, 175-186. PDF
115) Stronach,
B. E. and Perrimon, N. (2002) Activation of the JNK pathway during
dorsal closure in Drosophila requires the mixed lineage kinase, slipper.
Genes and Development 16, 377-387. PDF
116) Chen,
H.W., Marinissen, M. J., Oh, S.W., Chen, X., Melnick, M., Perrimon,
N. Gutkind, J.S., and Hou, S. X. (2002) CKA, a novel multidomain protein,
regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.
Mol. Cell. Biol. 6, 1792-1803. PDF
117) Micchelli,
C., The, I. Selva, E., Mogila, V. and and Perrimon, N. (2002) Rasp,
a putative transmembrane acyltransferase, is required for Hedgehog signaling.
Development 129, 843-851. PDF
118) Mathew,
D., Gramates, L. S., Packard, M., Packard, U., Thomas, U., Bilder,
D., Perrimon, N., Gorczyca, M., and Budnick, V. (2002) Recruitment of
Scribble to the synaptic scaffolding complex requires GUK-holder, a novel
DLG binding protein. Current Biology 12, 531-539.
PDF Supplement
119) Schöck,
F., and Perrimon, N. (2002) Cellular processes associated with germ
band retraction in Drosophila. Developmental Biology 248, 29-39. PDF Movie 1 Movie 2 Movie 3 Movie 4
120) Li,
W., Agaisse, H., Mathey-Prevot, B. and Perrimon, N. (2002) Differential
requirement for STAT by gain-of-function and wild-type receptor tyrosine
kinase Torso in Drosophila. Development 129, 4241-4248. PDF
121) Hrdlicka,
L., Gibson, M., Kiger, A., Micchelli, C., Schober, M., Schöck,
F. and Perrimon, N. (2002) Analysis of twenty four Gal4 lines in Drosophila
melanogaster. Genesis 34, 51-57. PDF
122) Boutros,
M., Agaisse, H. and Perrimon, N. (2002) Sequential activation of
signaling pathways during innate immune responses in Drosophila. Developmental
Cell 3, 711-722. PDF MicroArray
raw data Supplement 1 Supplement 2 Supplement 3 Supplement 4
123) Song.
H-J., Billeter, J-C., Reynaud, E., Carlo, T., Spana, E. P., Perrimon,
N., Goodwin, S. F., Baker, B. S. and Taylor, B. J. (2002) The fruitless
gene is required for the proper formation of axonal tracts in the embryonic
central nervous system of Drosophila. Genetics 162, 1703-1724. PDF
124) Wills,
Z., Emerson, M., Rusch, J., Bikoff, J., Baum, B., Perrimon, N. and
Van Vactor, D. (2002) A Drosophila homologue of Cyclase-associated proteins
collaborates with the Abl tyrosine kinase to control midline axon pathfinding.
Neuron 36, 611-622. PDF
125) Tan,
C., Stronach, B., and Perrimon, N. (2003) Roles of Myosin Phosphatase
during Drosophila development. Development 130, 671-681. PDF
126) Bilder,
D., Schober, M. and Perrimon, N. (2003) Integrated activity of PDZ
protein complexes regulates epithelial polarity. Nature Cell Biology 5,
53-58. PDF
127) Schöck,
F. and Perrimon, N. (2003) Retraction of the Drosophila germ band
requires cell-matrix interaction. Genes and Development 17, 597-602. PDF
128) Micchelli,
C., Esler, W. P., Kimberly, W. T., Jack, C., Berezovska, O., Kornilova,
A., Hyman, B. T., Perrimon, N. and Wolfe, M. S. (2003) g-Secretase/presenilin
inhibitors for Alheimer's disease phenocopy Notch mutations in Drosophila.
FASEB Journal 17, 79-81. PDF
129) Adam,
G., Perrimon, N. and Noselli, S. (2003) The retinoic-like juvenile
hormone controls the looping of left-right asymmetric organs in Drosophila.
Development 130, 2397-2406. PDF
130) Bashirullah,
A., Pasquinelli, A. E., Kiger, A., Perrimon, N., Ruvkun, G. and Thummel,
C. S. (2003) Coordinate regulation of small temporal RNAs at the onset
of Drosophila metamorphosis. Dev. Biol. 259, 1-8.PDF
131) Bach,
E. A., Vincent. S., Zeidler. M. and Perrimon, N. (2003) A sensitized
genetic screen to identify novel regulators and components of the Drosophila
JAK/STAT pathway. Genetics. 165, 1149-66. PDF
132) Lüders,
F., Segawa, H., Stein, D., Selva, E. M., Perrimon, N., Turco, S. J.
and Häcker, U. (2003) slalom encodes a PAPS transporter essential
for segment polarity and dorsal-ventral axis determination. EMBO J. 22,
3635-3644. PDF
133) Ghiglione,
G., Amundadottir, L., Andresdottir, M., Bilder, D., Diamonti, J. A.,
Noselli., Perrimon. N. and Carraway III, K. L. (2003) Mechanism of inhibition
of the Drosophila and mammalian EGF receptors by the transmembrane protein
Kekkon 1. Development 130, 4483-4493. PDF
134)
Agaisse, H., Petersen, U-M., Boutros, M., Mathey-Prevot, B. and Perrimon,
N. (2003) Signaling Role of Hemocytes in Drosophila JAK/STAT-Dependent
Response to Septic Injury. Developmental Cell 5, 441-450. PDF
135) Sasamura,
T., Sasaki, N., Miyashita, F., Nakao, S., Ishikawa, H. O., Ito, M.,
Kitagawa, M., Harigaya, K., Spana, E., Bilder, D., Perrimon, N. and Matsuno,
K. (2003) neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase
homolog that is essential for Notch-Delta interactions. Development 130,
4785-4795. PDF
136) Kiger,
A. A., Baum, B., Jones, S., Jones, M. R., Coulson, A., Echeverri,
C. and Perrimon, N. (2003) A functional genomic analysis of cell morphology
using RNA-interference. Journal of Biology 2 (4). PDF Supplement 1 Supplement 2
137) Cherry,
S. and Perrimon, N. (2004) Entry is a rate-limiting step for viral
infection in a Drosophila model for pathogenesis. Nature Immunology 5,
81-87. PDF
138) Boutros,
M., Kiger, A. A., Armknecht, S., Kerr, K. Hild, M., Koch, B., Haas,
S. A., Heidelberg Fly Array Consortium., Paro, R., and Perrimon, N. (2004)
Genome-Wide RNAi Analysis of Growth and Viability in Drosophila Cells.
Science 303. 832-835 PDF Supplement Table 1 Table 2
139)
Zeidler, M., Tan, C., Bellaiche, Y., Cherry, S., Häder, S., Gayko,
U. and Perrimon, N. (2004) Controlling protein activity with conditionally
splicing Inteins. Nature Biotechnology. 22, 871-876. PDF Supplement
140) Brückner,
K., Kockel, L., Duchek, P., Luque, C. M., Rørth, P., and Perrimon,
N. (2004) Control of blood cell survival and development by the Drosophila
PDGF/VEGF Receptor. Developmental Cell. 7, 73-84. PDF Supplement
141) Sinenko,
S. A., Kim, E-K., Wynn, R., Manfruelli, P., Ando, I., Wharton, K.
A., Perrimon. N. and Mathey-Prevot. B. (2004) Yantar, a conserved arginine-rich
protein is involved in Drosophila hemocyte development. Dev. Biol. 273,
48-62. PDF
142) Schlesinger,
A., Kiger, A., Perrimon, N. and Shilo, B-Z. (2004) Small wing PLCy
is required for ER retention of cleaved Spitz during eye development in
Drosophila. Developmental Cell. 7, 535-45. PDF Supplement 1 Supplement 2
143) Baeg,
G. H., Selva, E., Goodman, R., Dasgupta, R. and Perrimon, N. (2004)
The Wingless morphogen gradient is established by the cooperative action
of Frizzled and Heparan Sulfate Proteoglycans receptors. Dev Biol. 276,
89-100. PDF
144) Eggert,
U. S., Kiger, A. A., Perlman, Z. E., Perrimon,N., Mitchison, T. J.
and Field, C. M. (2004) Parallel RNAi and chemical screens identify cytokinesis
inhibitors and target pathways. PLOS. 2 e379. PDF Fig. 1 Fig. 2 Fig. 3 Supplement 1 Supplement 4 Supplement 5
145) Cherry,
S., Doukas. T., Armknecht, S., Wang, S. Wheeler, H., Sarnow, P.
and Perrimon, N. (2005) Genome-wide RNAi screen reveals a specific
sensitivity of IRES-containing RNA viruses to host translation inhibition.
Genes and Development 19 445-452. PDF Supplement
146) Gibson,
M. and Perrimon, N. (2005) Extrusion of TGF-beta compromised cells
from the Drosophila wing imaginal epithelium. Science 307
1785-1789. PDF Supplement
147) Hayward,
P., Brennan, K., Sanders, P., Balayo, T., Dasgupta, R., Perrimon,
N. and Martinez Arias, M. (2005) Notch modulates Wnt signalling by associating
with Armadillo/ßcatenin and regulates its transcriptional activity.
Development. 132 1819-1830 PDF Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5
148) Dasgupta,
R., Kaykas, A., Moon, R. T. and Perrimon, N. (2005). Functional genomic
analysis of the Wingless/Wnt signaling pathway.” Science 308. 826-832.
PDF Supplement
149) Schober,
M., Rebay, I. and Perrimon, N. (2005) Function of the ETS transcription
factor Yan in border cell migration. Development. 132, 3493-3504. PDF
Supplement
150) Philips,
J., Rubin, E. and Perrimon, N. (2005) Drosophila RNAi screen reveals
CD36 family member required for mycobacterial infection. Science. 309:
1251-1253. PDF Supplement
151) Agaisse,
H., Burrack, L., Philips, J., Rubin, E., Perrimon, N. and Higgins,
D. E. (2005) Genome-wide RNAi screen for host factors required for
intracellular bacterial infection. Science. 309: 1248-1251. PDF Supplement
152) Baeg,
G. H., Zhou, R. and Perrimon, N. (2005) Genome-wide RNAi analysis
of JAK/STAT signaling components in Drosophila. Genes and Development.
19(16):1861-70 PDF Addendum
153) Nybakken
K, Vokes SA, Lin TY, McMahon AP, Perrimon N. (2005) A genome-wide
RNA interference screen in Drosophila melanogaster cells for new
components of the Hh signaling Nat Genet. 37(12):1323-32. PDF
Supplement
154) Kirilly,
D., Spana, E., Perrimon,
N., Padgett, R. W., and Xie, T. (2005) BMP signaling is required for
controlling somatic stem cell self-renewal in the Drosophila ovary. Developmental
Cell. 9, 651-662. PDF Supplement
155) Flockhart,
I., Booker, M., Kiger. A., Boutros, M., Armknecht, S.,
Ramadan, N., Richardson, K., Xu, A., Perrimon, N. and Mathey-Prevot.
B. (2006) FlyRNAi: The Drosophila RNAi Screening Center Database. Nucleic
Acid Research. D489-94. PDF
156) Micchelli
C., and Perrimon, N. (2006) Evidence that stem cells reside in
the adult Drosophila midgut epithelium Nature. 439: 475-479 PDF Supplement
157) Bard,
F., Casano, L., Mallabiabarrena, A., Wallace, E., Saito,
K., Kitayama, H., Guizzunti, G., Hu, Y., Wendler, F., DasGupta, R., Perrimon,
N. and Malhotra, V. (2006) Functional genomics reveals genes involved
in protein secretion and Golgi organization. Nature. 439. 604-607. PDF Supplement
158) Karsten,
P., Plischke, I., Perrimon, N. and Zeidler, M. P. (2006) Mutational analysis
reveals separable DNA binding and trans-activation of Drosophila STAT92E. Cellular
Signaling. 18, 819-829. PDF
159) Chen,
L-Y., Wang, J-C., Hyvert, Y., Lin. H-P., Perrimon, N., Imler,
J-L. and Hsu, J-C. (2006) Weckle is a Zinc Finger adaptor of the Toll
pathway in dorsoventral patterning of the Drosophila Embryo.
Current Biology 16. 1183-1193. PDF Supplement
160) Gibson,
M. C. Patel, A., Nagpal, R. and Perrimon, N. (2006) The
emergence of geometric order in proliferating metazoan epithelia. Nature 442.
1038-1041. PDF Supplement
161) Kulkarni,
M. M., Booker M., Silver, S., Friedman, A., Hong, P.
Perrimon, N., and Mathey-Prevot, B. (2006) Evidence of off-target effects
associated with the use of long dsRNAs in Drosophila cell-based
assays. Nature Methods 3 833-838.PDF Supplement Excel 1 Excel 2
162) Friedman,
A. and Perrimon, N. (2006) A functional genomic RNAi
screen for novel regulators of RTK/ERK signaling. Nature 444,
230-234. PDF Supplement 1 Supplement 2 Supplement 3 Supplement 4 Supplement 5
163) Bach,
E. A., Ekas, L. A., Ayala-Camargo, A., Flaherty, M. S., Lee,
H. Perrimon, N. and Baeg, G-H. (2006) GFP reporters detect the activation
of the Drosophila JAK/STAT pathway in vivo. Gene Expression Patterns.
Epub ahead print. PDF
164) Cherry,
S., Kunte, A., Wang, H., Coyne, C., Rawson, R. H. and
Perrimon, N. (2006) COPI activity coupled with fatty acid biosynthesis
is required for viral replication. PLoS Pathog 2(10): e102. DOI: 10.1371/journal.ppat.0020102.
PDF Supplement
165)
Lu, J. Ruhf, M-L., Perrimon, N. and Leder, P. (2007) A genome-wide RNA
interference screen identifies putative chromatin regulators essential
for E2F repression. PNAS. 104, 9381-9386 PDF Supplements
166)
Bakal,
C., Aach, J., Church, G. and Perrimon, N. (2007) Quantitative
morphological signatures define local signaling networks regulating cell
morphology. Science 316,
1753-1756
PDF Supplement
167) Silver,
SJ., Hagen, JW., Okamura, K.,
Perrimon, N., and Lai, EC. (2007) Functional screening identifies
miR-315 as a potent activator of Wingless signaling. PNAS 104,18151-18156
PDF Supplement
168) DasGupta,
R., Nybakken, K., Booker, M., Mathey-Prevot,
B., Gonsalves,
F., Changkakoty, B. and Perrimon, N. (2007) A case study
of the reproducibility of transcriptional reporter cell-based RNAi screens
in Drosophila. Genome Biology. 8. R203. PDF Supplement
1 Supplement 2 Supplement
3 Supplement 4
169) Bai,
J., Hartwig, J. H., and Perrimon, N. (2007) SALS, a WH2-domain-containing
protein, promotes sarcomeric actin filament elongation from pointed ends
during Drosophila muscle growth. Developmental Cell 13, 828-842 PDF Supplement *
170) Vinegoni,
C., Pitsouli, C., Razansky, D., Perrimon, N. and Ntziachristos,
V. (2008) Live-cell imaging of Drosophila melanogaster pupae with mesoscopic
fluorescence tomography. Nature Methods 5, 45-47 PDF Supplement
171) Ni,
J-Q., Markstein, M., Binari, R., Pfeiffer, B., Liu, L-P.,
Villalta, C., Booker, M., Perkins, L. A., and Perrimon, N. (2008) Vector
and Parameters for Targeted Transgenic RNAi in Drosophila. Nature Methods
5, 49PDF -Supplement**
172) Wang
J, Zhou X, Bradley PL, Chang SF, Perrimon N, Wong ST. (2008) Cellular
phenotype recognition for high-content RNA interference genome-widescreening.
J Biomol Screen. 13(1):29-39. PDF
173) Philips
JA, Porto MC, Wang H, Rubin EJ, Perrimon N. 2008 ESCRT
factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. PNAS.
105, 3070-3075 PDF **Supplement
174) Bai, J., Binari, R., Ni, J-Q., Vijayakanthan, M.. Li, H-S.
and Perrimon, N. (2008) RNA interference screening in Drosophila primary
muscle cells for genes involved in muscle assembly and maintenance. Development.
135, 1439-1449. PDF Supplement*
175) Markstein,
M., Pitsouli, C., Villalta, C., Celniker, S. and Perrimon,
N. (2008) Exploiting position effects and the gypsy retrovirus insulator
to engineer precisely expressed transgenes. Nature Genetics. Epub
ahead of print PDF Supplement**
176) Czech,
B., Malone, C. D., Zhou, R., Stark, A., Schlingeheyde, C.,
Dus, N., Perrimon, N., Kellis, M., Wohlschlegel, J. A., Sachidanandam,
R., Hannon, G. H. and Brennecke, J. (2008) An endogenous small interfering
RNAi pathway in Drosophila. Nature. 453, 798-802. PDF Supplement
177) Yin,
Z.*, Zhou, X.*, Bakal, C.*,
Li, F., Sun, Y., Perrimon N. and Wong, S. (2008). Using iterative cluster
merging with improved gap statistics to perform online phenotype discovery
in the context of high-throughput RNAi screens. BMC Bioinformatics 2008,
9:264. PDF Supplement *
178) Sepp,
K. J., Hong, P., Lizarraga, S. B., Liu, J. S., Mejia, L.
A., Walsh, C. A. and Perrimon, N. (2008) Identification of neural outgrowth
genes using genome-wide RNAi. PLoS Genetics. 7: e1000111. PDF* Supplement
179) Vincent
S, Perrimon N, Axelrod JD.
(2008) Hedgehog and Wingless stabilize but do not induce cell fate during
Drosophila dorsal embryonic epidermal patterning. Development. 135, 2767-2775 PDF Supplement
180) Bakal,
C., Linding R., Llense, F., Heffern, E., Martin-Blanco,
E., Pawson, T. and Perrimon, N. (2008) Systems analysis of the phosphorylation
networks that regulate JNK activity in diverse genetics backgrounds.
Science. 322, 453-456. PDF** Supplement
181) Zhou,R., Hotta, I., Denli, AM., Hong, P., Perrimon, N. and Hannon,
GJ. (2008) Comparative Analysis of Argonaute-Dependent Small RNA Pathways
in Drosophila. Molecular Cell. 32 (4), 592-599. PDF** Supplement
182) Demontis,
F and Perrimon, N(2009) Integration of Insulin
receptor/Foxo signaling and dMyc activity during muscle growth regulates
body size in Drosophila Development 136, 983-993. PDFSupplement
183) Zhang,
S., Feany, MB., Saraswati, S., Littleton, JT., Perrimon, N. (2009)
Inactivation of Drosophila Huntingtin affects long-term adult functioning
and the pathogenesis of a Huntington's disease model. Dis Model Mech.
[Epub ahead of print] PDF Suuplement 1 Supplement 2 Supplement 3 Supplement 4 Supplement 5 Supplement 6 Supplement 7 Supplement 8 Movies also available
184)
Ni
JQ, Liu LP, Binari R, Hardy R, Shim HS, Cavallaro A, Booker M, Pfeiffer
B, Markstein M, Wang H, Villalta C, Laverty T, Perkins L, Perrimon N.
(2009) A Drosophila Resource of Transgenic RNAi Lines for Neurogenetics.
Genetics. [Epub ahead of print]PDF Supplements
185) Kaplow IM, Singh R, Friedman A, Bakal C, Perrimon N, Berger B.
(2009) RNAiCut: automated detection of significant genes from functional
genomic screens. Nat Methods. 6(7), 476-7. PDF Supplement
186) Brouzes
E, Medkova M, Savenelli N, Marran D, Twardowski M, Hutchison
JB, Rothberg JM, Link DR, Perrimon N, Samuels ML. (2009) Droplet microfluidic
technology for single-cell high-throughput screening. Proc Natl Acad Sci
USA. Jul 15. [Epub ahead of print] PDF Supplement
187) Griffin
R, Sustar A, Bonvin M, Binari R, del Valle Rodriguez A,
Hohl AM, Bateman JR, Villalta C, Heffern E, Grunwald D, Bakal C, Desplan
C, Schubiger G, Wu CT, Perrimon N. (2009) The twin spot generator for
differential Drosophila lineage analysis. Nat Methods. 6(8):
600-2. PDF Supplement
188) Zhou
R, Czech B, Brennecke J, Sachidanandam R, Wohlschlegel JA,
Perrimon N, Hannon GJ. (2009) Processing of Drosophila endo-siRNAs depends
on a specific Loquacious isoform. RNA. Jul 27 [Epub ahead of print]
PDF* Supplemental Information
189)
Ni
JQ, Liu, L-P., Binari, R., Hardy, R., Shim, H-S., Cavallaro, A., Booker, M., Pfeiffer, B., Markstein, M., Wang, H., Villalta, C., Laverty, T. R., Perkins, L. A. and Perrimon, N. (2009) A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 182, 1089-1100PDF Supplement
190) Celniker, S.E., Dillon, L. A., Gerstein, M.B., Gunsalus, K.C., Henikoff, S., Karpen, G.H., Kellis, M., Lai, E.C., Lieb, J.D., MacAlpine, D.M., Micklem, G., Piano, F., Snyder, M., Stein, L., White, K.P., Waterston, R.H., and modENCODE Consortium. (2009) Unlocking the secrets of the genome. Nature. 459, 927-30.
191) Zhou, R., Czech, B., Brennecke, J., Sachidanandam, R., Wohlschlegel, J. A., Perrimon, N. and Hannon, G. J. (2009) Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA. 15, 1886-1895.
192) Kondo, S., Booker, M. and Perrimon, N. (2009) Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics. 183, 1165-1173.
193) Czech, B., Zhou, R., Erlich, Y., Brennecke, J., Binari, R., Villalta, C., Gordon, A., Perrimon, N. and Hannon, G. J. (2009) Hierarchical rules for Argonaute loading in Drosophila. Molecular Cell. 36, 445-456.
194) Apidianakis, Y., Pitsouli, C., Perrimon, N. and Rahme, L. (2009) Infection increases stem cell proliferation to promote intestinal dysplasia in Drosophila. PNAS. In Press.
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