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Aimée M. Dudley
Department of Genetics
Harvard Medical School
77 Avenue Louis Pasteur
Boston, MA 02115 USA
|  | Tel: (617) 432-7670
Fax: (617) 432-7266
dudley@genetics.med.harvard.edu |
Education
Doctor of Philosophy, Genetics (November 1999)
Harvard Medical School
Bachelor of Science, Biochemistry and Molecular Biology (May 1992)
University of Massachusetts at Amherst
Research Experience
Postdoctoral Fellow, Harvard Medical School (October 1999 - Present)
George Church, Advisor
| Development of DNA microarray technologies that measure gene expression on an absolute scale; development and application of low-cost, high-throughput methods for large-scale quantitation of mutant phenotype; experimental and computational analysis of genetic and metabolic networks; systems biology approaches relevant to understanding and modeling the cell cycle and mitochondrial function in Saccharomyces cerevisiae. |
Doctoral Student, Harvard Medical School (September 1992 - October 1999)
Fred Winston, Advisor
| Genetic, molecular, and biochemical analysis of the mechanisms by which the SAGA complex regulates promoter activity in Saccharomyces cerevisiae. |
Senior Honors Thesis, University of Massachusetts at Amherst (June 1991 - August 1992)
Jennifer Pinkham and Thomas Mason, Advisors
| Development of a regulated, in vivo transcription system for expressing functional mitochondrial proteins in Saccharomyces cerevisiae and application to translational regulation. |
Honors Study, University of Massachusetts at Amherst (September 1990 - August 1991)
Dennis Searcy, Advisor
| Study of Thermoplasma acidophilium growth rates under sulfur-respiring conditions and superoxide dismutase enzyme kinetics with sulfur-containing substrates. |
Teaching Experience
Laboratory Advisor: Graduate, undergraduate, high school students (2000 - Present)
Harvard Medical School
Instructor and Mentor: Mentoring for Science Program (2000 - 2004)
Harvard Medical School and Boston Public Schools
Teaching Assistant: Introductory genetics course (1995)
Harvard Medical School
Current Funding
Genome Scholar and Faculty Transition Award K22 (August 2003-2008)
National Institutes of Health/ National Human Genome Research Institute
Awards and Honors
Alexander Hollaender Distinguished Postdoctoral Fellowship (2000-2002)
United States Department of Energy
Departmental and University Honors, magna cum laude (1992)
University of Massachusetts at Amherst
Chancellor's Talent Award (1988-1992)
Full-tuition scholarship, University of Massachusetts at Amherst
Commonwealth Scholar Grant (1988-1989)
Publications
Lee, S., D. Pe’er, A. M. Dudley, G. M. Church, and D. Koller.
Identifying regulatory mechanisms using their individual variation reveals key role for chromatin modification, manuscript in preparation.
Dudley, A. M.*, D. Segrè*, D. M. Janse, K. Wong, and G. M. Church.
Measuring and modeling the yeast physiome, manuscript in preparation.
Dudley, A. M.*, D. M. Janse*, A. Tanay, R. Shamir, and G. M. Church.
A global view of pleiotropy and phenotypically derived gene function in yeast. Mol. Systems Biol. msb4100004:E1. Extended Synopsis | Download PDF
Dudley, A. M. and D. L. Cardozo.
Introduction to biological research: a laboratory course. American Biology Teacher 68: 14-24. Download PDF
King, O. D., J. C. Lee, A. M. Dudley, D. M. Janse, G. M. Church, F. P. Roth.
Predicting phenotype from patterns of annotation. (2003) Bioinformatics 19 (Suppl. 1): i183-i189. Download PDF
Dudley, A. M.*, J. Aach*, M. A. Steffen, and G. M. Church.
Measuring absolute expression with microarrays using a calibrated reference sample and an extended signal intensity range. (2002) PNAS 99:7554-9. Download PDF
Dudley, A. M., C. Rougeulle, and F. Winston.
The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. (1999) Genes & Dev. 13: 2940-2945. Download PDF
Dudley, A. M., L. J. Gansheroff, and F. Winston.
Specific components of the SAGA complex are required for Gcn4- and Gcr1-mediated activation of the his4-912d promoter in Saccharomyces cerevisiae. (1999) Genetics 151: 1365-1378.
Download PDF
Madison, J. M., A. M. Dudley, and F. Winston.
Identification and analysis of MOT3, a zinc finger protein that binds to the retrotransposon Ty long terminal repeat (d) in Saccharomyces cerevisiae. (1998) Mol. Cell. Biol. 18: 1879-1890. Download PDF
Pinkham, J. L., A. M. Dudley, and T. L. Mason.
T7 RNA polymerase-dependent expression of COXII in yeast mitochondria. (1994) Mol. Cell. Biol. 14: 4643-4652. Download PDF
*equal contributions
Invited Seminars
University of Massachusetts Department of Microbiology (April 6, 2005)
Amherst, Massachusetts
Harvard Bauer Center for Genomic Research (March 30, 2005)
Cambridge, Massachusetts
Boston University, Systems Biology Course Lecture (February 15, 2005)
Boston, Massachusetts
Yeast Genetics and Molecular Biology Meeting (August 3, 2002)
University of Wisconsin, Madison
MIT Microarray Club (May 15, 2002)
Massachusetts Institute of Technology
Penn Bioinformatics Forum (April 17, 2002)
University of Pennsylvania
MGED IV (February 15, 2002)
Boston, Massachusetts
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