Myosin, etc.

• Our Hypertrophic Cardiomyopathy / Sarcomere Gene Mutation Database, with information about known disease mutations in the human beta-cardiac myosin heavy chain gene. This is part of NHLBI's CardioGenomics project.
• References to standards for mutation nomenclature and mutation database structure
• Search our FHC Mutation Database by DNA sequence, to see if your sequence query matches a known mutated amplimer sequence.
• An interactive alignment of five myosin heavy chain protein sequences: human beta-cardiac (with disease mutations), chicken skeletal, scallop, chicken smooth muscle, and Dictyostelium. Click on the red mutation residues to display a 3-D model of the protein with the mutation's position highlighted. (WARNING: a 350-kB download!)
• A 3D rendering of human beta-cardiac myosin (created using Molscript / Raster3D ), showing locations of mutations (discovered in our lab and others') that cause Familial Hypertrophic Cardiomyopathy. (73 kB JPEG)
  Here are the script and the PDB file (664 KB) that I used to create the image.
• A page of Molscript color names, sorted by RGB hex value or alphabetically by name.
• The same myosin image as above, this time rendered with RasMol
  It's not as pretty, but RasMol is interactive, fast, and runs on most platforms. Here's my RasMol script .
• Alignment in GCG Pileup format of those myosin sequences which have had their crystal structures determined: chicken skeletal, scallop, chicken smooth, and Dictyostelium, with human beta-cardiac myosin.
• Secondary structure assignments for chicken skeletal myosin, in an alignment as above (but not interactive). Edited from a huge alignment of all known myosin sequences at the Myosin Home Page at Cambridge University.
• The Familial Hypertrophic Cardiomyopathy mutation database from David C.Y. Fung at the Australian National Genomic Information Service.
• Actin-myosin figures and animations from Kenneth Holmes's lab, Max Planck Institute.
• Actin-myosin figures and animations (including an excellent Quicktime/MPEG movie) from Ron Milligan's lab, Scripps Institute.
• Willy Wriggers's page on molecular dynamics simulations of actin, Univ. of Illinois.
• An animation of an actin-myosin 3D crossbridge in action from San Diego State University. (460 kB GIF)
• David Goodsell's "Molecule of the Month" article on myosin at PDB.