Discrimination between the Yap1p and Yap2p transcriptional networks using microarray analysis

Supplementary information to the article

Barak Cohen, Yitzhak (Tzachi) Pilpel, Robi Mitra, and George M. Church
Department of Genetics, Harvard Medical School, and Lipper Center for Computational Genetics

Molecular Phenotypes of yap1 and yap2 mutants
Yap Motif Logos and Matricies
Click on the links below to view binding site sequence logos for the motifs found upstream of  Yap1p and Yap2p dependent genes.  The binding site matricies that were used to construct the logos are also included.
Sequence Logo of Yap1p Binding Site
Sequence Logo of Yap2p Binding Site

Cluster analysis of clusters

The dendrogram below depicts the relationship between the expression clusters derived from the microarray experiments.  The average expression profiles for the genes in each of the clusters were used to group together clusters in which the genes showed similar expression patterns. Click on the links below the tree to view the expression profiles, genes, and upstream motifs associated with each cluster.
Cluster1 Cluster3Cluster4 Cluster8Cluster9 Cluster16Cluster17 Cluster19Cluster22 Cluster26Cluster30 Cluster31Cluster33 Cluster34Cluster39 Cluster43Cluster46 Cluster51Cluster54 Cluster57Cluster60 Cluster63Cluster68 Cluster79Cluster82 Cluster86Cluster89

Data & Resources

All expression data were taken from ExpressDB

Motifs were derived using AlignACE and matched to promoters in the genome using ScanACE