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Matthew Jakubik
Harvard Medical School Department of Genetics 77 Avenue Louis Pasteur New Research Building, Rm 264 Boston, MA 02115 fax (617)432-7663
Research InterestsMy research focuses on how cis and trans chromosomal interactions
affect gene regulation and chromatin structure. My research will
examine how such interactions affect chromatin structure.
Additionally, pairing of maternal and paternal homologous chromsomes
in Drosophila allows for a process called transvection, whereby
expression of a gene is sensitive to the proximity of its homologue.
Two types of transvection have been determined to occur at the yellow
locus, enhancer action in trans and insulator bypass in cis. My
studies will address the molecular mechanism mediating insulator
bypass in cis. Lastly, my research will examine the dynamics of
enhancer-promoter communication in cis and trans. |
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